Precision Medicine for Neonatal Sepsis

Towards precision medicine for sepsis patients

Over the last decade it has become clear that the immunological response and clinical course in sepsis patients is too complex to simply regard it as ‘hyperinflammation-induced organ failure’. In contrast to the previous belief that patients mainly suffer from an exaggerated pro-inflammatory response, it has now become evident that a proand anti-inflammatory response are mounted simultaneously ...

Genetics and neonatal diabetes: towards precision medicine

934 www.thelancet.com Vol 386 September 5, 2015 Diabetes is a lifelong chronic disease. During the past 100 years, its diagnosis has been based on measurements of raised blood glucose concentrations. In the 1960s, diabetes was subclassifi ed based on age at onset and need for insulin treatment (ie, juvenile or maturity onset; insulin or non-insulinrequiring diabetes). Because diabetes was belie...

Neonatal Sepsis: An Update

Sepsis is the most common cause of neonatal mortality. As per National Neonatal-Perinatal Database (NNPD), 2002-2003, the incidence of neonatal sepsis in India was 30 per 1000 live births. Signs and symptoms of sepsis are nonspecific; therefore empirical antimicrobial therapy is promptly initiated after obtaining appropriate cultures. The early manifestations of neonatal sepsis are vague and il...

precision medicine for endocrinology

Procalcitonin: A Reliable Marker for the Diagnosis of Neonatal Sepsis

Objective(s) In the last few years, serum procalcitonin has been proposed as an early marker of infections in neonates, with varying results. In this study, we aimed to investigate the value of procalcitonin, and C- reactive protein in establishing the diagnosis of neonatal sepsis. Materials and Methods Blood samples were collected at admission from 69 neonates with suspected infection (admi...